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The in vitro results showed that CYP3A4 was the major human P450 enzyme catalyzing the biotransformation of imatinib.
Since the renal clearance of imatinib is negligible, a decrease in total body clearance is not expected in patients with renal insufficiency.
A structured assessment was carried out of the Novartis economic evaluation of imatinib for unresectable and/or metastatic gist.
Knowing this allowed for the creation of a drug called Imatinib, which inhibits this process.